Kévin ALEXANDRE

MCU-PH – Rouen

kevin.alexandre@chu-rouen.fr
Accueil PRÉSENTATION DE L’UNITE Composition de l’unité Kévin ALEXANDRE
Kevin Alexandre

52 documents

Articles dans une revue32 documents

  • Charlotte Charpentier, Thomas Montrouge, Marc Wirden, Véronique Avettand-Fenoel, Camille Tumiotto, et al.. A French national observatory of people with HIV initiating lenacapavir-based treatment after regulatory approval. Antimicrobial Agents and Chemotherapy, 2026, pp.e0022826. ⟨10.1128/aac.00228-26⟩. ⟨hal-05657906⟩
  • José Pedro Cidade, Fabio Silvio Taccone, Luis Felipe Reyes, Laura Merson, Benjamin Lefèvre, et al.. Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients. Intensive Care Medicine Experimental, 2026, 14 (1), pp.14. ⟨10.1186/s40635-026-00864-x⟩. ⟨hal-05501498⟩
  • K Alexandre, Marina Murillo-Torres, Fernando Docobo-Pérez, Álvaro Pascual, Jose Manuel Rodríguez-Martínez. Effect of pH on antimicrobial activity of delafloxacin against Escherichia coli isogenic strains carrying diverse chromosomal and plasmid-mediated fluoroquinolone resistance mechanisms. Microbiology Spectrum, 2025, 13 (12), pp.e0233825. ⟨10.1128/spectrum.02338-25⟩. ⟨hal-05352146⟩
  • Charles Baulier, Noémie Le Dentu, Mathieu Lozouet, Yves Kam, Gaétan Kerdelhué, et al.. Linezolid use in post-neurosurgical central nervous system infections: A systematic review. Neurosurgical Review, 2025, 48 (1), pp.714. ⟨10.1007/s10143-025-03891-6⟩. ⟨hal-05319080⟩
  • Charles Baulier, Marion Giry, Manuel Etienne, Julien Kallout, Kévin Alexandre. Pharmacokinetic/pharmacodynamic targets of ß-lactams associated with bacterial killing and suppression of the resistance emergence in the hollow fiber infection model: A systematic review. Journal of Global Antimicrobial Resistance, 2025, 45, pp.220 - 227. ⟨10.1016/j.jgar.2025.10.009⟩. ⟨hal-05352140⟩
  • Nicolas Vautrin, Sandrine Dahyot, Marie Leoz, François Caron, Maxime Grand, et al.. Are Escherichia coli causing recurrent cystitis just ordinary uropathogenic E. coli (UPEC) strains?. Virulence, 2024, 16 (1), pp.57. ⟨10.1080/21505594.2024.2444689⟩. ⟨hal-04920727⟩
  • Tifany Vatignez, Ludovic Lemée, Hélène Morisse-Pradier, Priscille Carvalho-Lallement, Kevin Alexandre, et al.. A 52-year-old immunocompromised man with an unusual cause of infectious lung cavitary inducing acute respiratory failure. Respiratory Medicine and Research, 2024, 86 (10), pp.101101. ⟨10.1016/j.resmer.2024.101101⟩. ⟨hal-05308614⟩
  • Kévin Alexandre, André Gillibert, Sandrine Dahyot, Roland Fabre, Francis Kuhn, et al.. Individual health insurance data of antibiotic delivery in previous months as a tool to predict bacterial resistance of urinary tract infection: A prospective cohort study. Infectious Diseases Now, 2024, 54 (6), pp.104942. ⟨10.1016/j.idnow.2024.104942⟩. ⟨hal-04669488⟩
  • Munib Mesinovic, Xin Ci Wong, Giri Shan Rajahram, Barbara Wanjiru Citarella, Kalaiarasu Peariasamy, et al.. At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods. Scientific Reports, 2024, 14 (1), pp.16387. ⟨10.1038/s41598-024-63212-7⟩. ⟨hal-04831133v2⟩
  • Barbara Wanjiru Citarella, Christiana Kartsonaki, Elsa D Ibáñez-Prada, Bronner P Gonçalves, Joaquin Baruch, et al.. Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms. Heliyon, 2024, 10, pp.e29591. ⟨10.1016/j.heliyon.2024.e29591⟩. ⟨hal-04702019⟩
  • Barbara Wanjiru Citarella, Christiana Kartsonaki, Elsa Ibáñez-Prada, Bronner Gonçalves, Joaquin Baruch, et al.. Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms. Heliyon, 2024, 10 (10), pp.e29591. ⟨10.1016/j.heliyon.2024.e29591⟩. ⟨hal-04831141⟩
  • Sung-Min Cho, Lavienraj Premraj, Denise Battaglini, Jonathon Paul Fanning, Jacky Suen, et al.. Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study. Brain Communications, 2024, 6 (2), pp.44. ⟨10.1093/braincomms/fcae036⟩. ⟨hal-04831170⟩
  • Félix Camirand-Lemyre, Laura Merson, Bharath Kumar Tirupakuzhi Vijayaraghavan, Aidan Burrell, Barbara Wanjiru Citarella, et al.. Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19. JAMA Network Open, 2023, 6 (12), pp.e2346502. ⟨10.1001/jamanetworkopen.2023.46502⟩. ⟨hal-04372873⟩
  • Denise Battaglini, Nicole White, Lavienraj Premraj, Barbara Wanjiru Citarella, Laura Merson, et al.. Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study. Journal of Neurology, 2023, 271 (1), pp.79-86. ⟨10.1007/s00415-023-12133-y⟩. ⟨hal-04399136⟩
  • Marine Stoldick, Margot Vannier, Mikael Verdalle-Cazes, Manuel Etienne, Kévin Alexandre. Short-Course Versus Prolonged-Course Antimicrobial Therapy in Adults With Catheter-Related Septic Thrombosis: A Propensity-Weighted Retrospective Study. Open Forum Infectious Diseases, 2023, 10 (11), ⟨10.1093/ofid/ofad530⟩. ⟨hal-04853526⟩
  • Nicolas Vautrin, Kévin Alexandre, Martine Pestel-Caron, Estelle Bernard, Roland Fabre, et al.. Contribution of Antibiotic Susceptibility Testing and CH Typing Compared to Next-Generation Sequencing for the Diagnosis of Recurrent Urinary Tract Infections Due to Genetically Identical Escherichia coli Isolates: a Prospective Cohort Study of Cystitis in Women. Microbiology Spectrum, 2023, 11 (4), ⟨10.1128/spectrum.02785-22⟩. ⟨hal-05224420⟩
  • Marina Wainstein, Nicholas Spyrison, Danyang Dai, Moji Ghadimi, Jonathan Chávez-Iñiguez, et al.. Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19. Kidney International Reports, 2023, 8 (8), pp.1514-1530. ⟨10.1016/j.ekir.2023.05.015⟩. ⟨hal-04338529⟩
  • Matthew Griffee, Patricia Bozza, Luis Felipe Reyes, Devin Eddington, Dorothea Rosenberger, et al.. Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry. Research and Practice in Thrombosis and Haemostasis, 2023, 7 (5), pp.102142. ⟨10.1016/j.rpth.2023.102142⟩. ⟨hal-04338492⟩
  • Christiana Kartsonaki, J Kenneth Baillie, Noelia García Barrio, Joaquín Baruch, Abigail Beane, et al.. Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19. International Journal of Epidemiology, 2023, 52 (2), pp.355-376. ⟨10.1093/ije/dyad012⟩. ⟨hal-04164628⟩
  • Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Laura Merson, Elsa Ibáñez-Prada, et al.. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Critical Care, 2022, 26 (1), pp.276. ⟨10.1186/s13054-022-04155-1⟩. ⟨hal-03932306v2⟩
  • Ali Abbas, Sheryl Ann Abdukahil, Nurul Najmee Abdulkadir, Ryuzo Abe, Laurent Abel, et al.. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. Scientific Data , 2022, 9 (1), pp.454. ⟨10.1038/s41597-022-01534-9⟩. ⟨hal-03830494⟩
  • Guillaume Martin-Blondel, François-Xavier Lescure, Lambert Assoumou, Charlotte Charpentier, Jean-Marc Chapplain, et al.. Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study. BMC Infectious Diseases, 2022, 22 (1), pp.540. ⟨10.1186/s12879-022-07508-x⟩. ⟨hal-03727828⟩
  • Marion Giry, Sacha Sarfati, Martine Pestel-Caron, Julien Wils, Fabien Lamoureux, et al.. Comment on: Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy, 2022, ⟨10.1093/jac/dkac150⟩. ⟨hal-03670777⟩
  • Agnès Cottalorda, Sandrine Dahyot, Anaïs Soares, Kevin Alexandre, Isabelle Zorgniotti, et al.. Phenotypic and genotypic within-host diversity of Pseudomonas aeruginosa urinary isolates. Scientific Reports, 2022, 12, ⟨10.1038/s41598-022-09234-5⟩. ⟨insu-03665281⟩
  • Ali Abbas, Sheryl Ann Abdukahil, Nurul Najmee Abdulkadir, Ryuzo Abe, Laurent Abel, et al.. The value of open-source clinical science in pandemic response: lessons from ISARIC [Comment]. The Lancet Infectious Diseases, 2021, 21 (12), pp.1623-1624. ⟨10.1016/S1473-3099(21)00565-X⟩. ⟨pasteur-04098113⟩
  • Sheryl Ann Abdukahil, Ali Ait Hssain, Younes Ait Tamlihat, Kazali Enagnon Alidjnou, Carlos Alexandre Antunes de Brito, et al.. COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. Infection, 2021, 49 (5), pp.889-905. ⟨10.1007/s15010-021-01599-5⟩. ⟨hal-03273644⟩
  • David Debeaumont, Fairuz Boujibar, Eglantine Ferrand-Devouge, Elise Artaud-Macari, Fabienne Tamion, et al.. Cardiopulmonary Exercise Testing to Assess Persistent Symptoms at 6 Months in People With COVID-19 Who Survived Hospitalization: A Pilot Study. Physical Therapy, 2021, 101 (6), pzab099. ⟨10.1093/ptj/pzab099⟩. ⟨hal-05306279⟩
  • Yazdan Yazdanpanah, Alpha Diallo, Christelle Paul, Noémie Mercier, Soizic Le Mestre, et al.. Impact on disease mortality of clinical, biological, and virological characteristics at hospital admission and overtime in COVID‐19 patients. Journal of Medical Virology, 2021, 93 (4), pp.2149-2159. ⟨10.1002/jmv.26601⟩. ⟨hal-04121463⟩
  • Viet-Thi Tran, Matthieu Mahévas, Firouze Bani-Sadr, Olivier Robineau, Thomas Perpoint, et al.. Corticosteroids in patients hospitalized for COVID-19 pneumonia who require oxygen: observational comparative study using routine care data. Clinical Microbiology and Infection, 2021, 27 (4), pp.603-610. ⟨10.1016/j.cmi.2020.11.035⟩. ⟨hal-03687923⟩
  • Mathilde Réveillon-Istin, Dabor Resiere, Sandrine Dahyot, Kévin Alexandre, Hossein Mehdaoui, et al.. Cellulitis and bacteremia after a snake bite despite antibiotic preemptive treatment: A diagnosis challenge. Travel Medicine and Infectious Disease, 2020, 35 (1), pp.101555. ⟨10.1016/j.tmaid.2020.101555⟩. ⟨hal-05320317⟩
  • Anaïs Soares, Kévin Alexandre, Fabien Lamoureux, Ludovic Lemée, Francois Caron, et al.. Efficacy of a ciprofloxacin/amikacin combination against planktonic and biofilm cultures of susceptible and low-level resistant Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, 2019, 74 (11), pp.3252-3259. ⟨10.1093/jac/dkz355⟩. ⟨hal-02343583⟩
  • Kévin Alexandre, Anaïs Soares, Françoise Chau, Bruno Fantin, Francois Caron, et al.. Temocillin breakpoints in pyelonephritis: evaluation in a murine model due to ESBL-producing Escherichia coli clinical isolates. Journal of Antimicrobial Chemotherapy, 2019, 74 (5), pp.1323-1326. ⟨10.1093/jac/dky569⟩. ⟨hal-02372777⟩

Communications dans un congrès1 document

  • Marion Giry, Kévin Alexandre. IMPLÉMENTATION DU MODÈLE HFIM EN NORMANDIE. Rencontres Normandes de Microbiologie, May 2023, Rouen (Université de Rouen Normandie), France. ⟨hal-04185170⟩

Poster de conférence18 documents

  • Marion Giry, Clément Marlat, Charles Baulier, Fabien Lamoureux, Ariella Ganem, et al.. Efficacy of different Piperacillin-Tazobactam -Amikacin regimens against ESBL Escherichia coli in a Hollow Fiber Infection Model simulating sepsis augmented renal clearance. ECCMID, Apr 2025, Vienne, Austria. ⟨hal-05222678⟩
  • Clément Marlat, Marion Giry, Charles Baulier, Manuel Etienne, François Gravey, et al.. In Vitro efficacy of Cefepime/Enmetazobactam against AmpC ßlactamase-producing Enterobacterales. ECCMID, Apr 2025, Vienne, Austria. ⟨hal-05222646⟩
  • Kévin Alexandre, C Sauco Carballo, M Murillo-Torres, F Docobo Perez, J M Rodriguez, et al.. Effect of pH on the bacteriostatic and bactericidal activities of Delafloxacin against Escherichia coli isogenic strains harboring diverse chromosomal and plasmid-mediated fluoroquinolone resistance mechanisms. ECCMID, Apr 2025, Vienne, Austria. ⟨hal-05222690⟩
  • Marion Giry, Clément Marlat, Charles Baulier, Fabien Lamoureux, François Gravey, et al.. Effect of augmented renal clearance on in vitro bactericidal activity of Cefepime-Enmetazobactam against ESBL-producing Escherichia coli evaluated via a mechanism-based modeling. ECCMID, Apr 2025, Vienne, Austria. ⟨hal-05222657⟩
  • Nassim Boutouchent, Isabelle Gueit, Julien Wils, Manuel Etienne, Sandrine Dahyot, et al.. Surdosage en ß lactamines au cours du traitement par amoxicilline ceftriaxone dans l'endocardite infectieuse à Enterococcus faecalis : épidémiologie et devenir des patients. 24èmes Journées Nationales d'Infectiologie, Jun 2023, Grenoble, France. ⟨hal-04185346⟩
  • Nicolas Vautrin, Sandrine Dahyot, Marie Leoz, François Caron, Maxime Grand, et al.. Recurrent cystitis episodes are caused by "ordinary" uropathogenic Escherichia coli strains. 33rd European congress of clinical microbiology and infectious diseases (ECCMID), Apr 2023, Copenhague, Denmark. ⟨hal-04184212⟩
  • Nassim Boutouchent, Fabien Lamoureux, Manuel Etienne, Julien Wils, Sandrine Dahyot, et al.. Therapeutic drug monitoring in patients with infective endocarditis treated with amoxicillin plus ceftriaxone. 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), Apr 2023, Copenhagen, Denmark. 23, 2019. ⟨hal-04184240⟩
  • Marine Stoldick, Margot Vannier, Mikael Verdalles-Cazes, Manuel Etienne, Kévin Alexandre. Short-Course Versus Prolonged-Course Antimicrobial Therapy in Adults With Catheter-Related Septic Thrombosis: a Propensity-Weighted Retrospective Study. ECCMID, Apr 2023, Copenhagen, Denmark. ⟨hal-04184293⟩
  • V Pargny, N Vautrin, O Minlong, D Ribet, M Pestel-Caron, et al.. In vitro activity of hydroxychloroquine in combination with antibiotics against uropathogenic Escherichia coli intracellular bacterial colonies. 33rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2023), Apr 2023, Copenhague, Denmark. ⟨hal-04184217⟩
  • C. Marlat, Julien Grosjean, T. Pressat Laffouilhere, Manuel Etienne, Kévin Alexandre, et al.. Efficacy of antimicrobial-lock therapy in catheter-related bloodstream infection. 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), Apr 2023, Copenhagen, Denmark. ⟨hal-04184248⟩
  • V Pargny, N Vautrin, O Minlong, D Ribet, M Pestel-Caron, et al.. Activité d'associations Hydroxychloroquine-Antibiotique vis-à-vis de colonies bactériennes intracellulaires d'Escherichia coli. RICAI 2022, Dec 2022, Paris, France. ⟨hal-04034434⟩
  • Nicolas Vautrin, Kévin Alexandre, David Ribet, Sandrine Dahyot, Marie Leoz, et al.. Place des rechutes et de l'invasion de la paroi vésicale dans la physiopathologie des cystites récidivantes à Escherichia coli. Journée Normande de Recherche Biomédicale (JNRB 2022), Jun 2022, Rouen, France. ⟨hal-03706255⟩
  • A Cottalorda, S Dahyot, A Soares, K Alexandre, M Etienne, et al.. Caractéristiques cliniques des infections ou colonisations urinaires à Pseudomonas aeruginosa. RICAI, Dec 2018, Paris, France. ⟨hal-02270974⟩
  • A Cottalorda, S Dahyot, A Soares, K Alexandre, M Etienne, et al.. Infections ou colonisations urinaires liées à Pseudomonas aeruginosa : caractéristiques cliniques des patients. 3ème Journée Normande de Recherche Biomédicale, Sep 2018, Rouen, France. . ⟨hal-02268707⟩
  • N Vautrin, S Dahyot, R Fabre, M Etienne, M. Pestel-Caron, et al.. Escherichia coli : caractérisation moléculaire de souches de cystites récidivantes. 3ème Journée Normande de Recherche Biomédicale, Sep 2018, Rouen, France. . ⟨hal-02268733⟩
  • Mathilde Réveillon-Istin, Kévin Alexandre, Roland Fabre, Valérie Delbos, Manuel Etienne, et al.. Cystites donnant lieu à ECBU en ville : Étude prospective de 529 cas. Journées Nationales d'Infectiologie, Jun 2018, Nantes, France. ⟨hal-02131944⟩
  • Mathilde Réveillon-Istin, Kévin Alexandre, Roland Fabre, Valérie Delbos, Manuel Etienne, et al.. Cystites : l'antibiorésistance est très dépendante du terrain. RICAI, Dec 2017, Paris, France. ⟨hal-02269349⟩
  • K Alexandre, A Soares, F Caron, M Etienne. Témocilline : concentration critique à 16mg/L d'après un modèle de pyélonéphrite à souches cliniques. Journée Normande de Recherche Biomédicale, Nov 2017, Caen, France. ⟨hal-02266187⟩

Thèses1 document

  • Kévin Alexandre. Evaluation expérimantale des concentrations critiques de la témocilline vis-à-vis de souches d'entérobactérales.. Médecine humaine et pathologie. Normandie Université, 2019. Français. ⟨NNT : 2019NORMR074⟩. ⟨tel-02435131⟩

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